This story was used with permission from the University of Minnesota.
A molecular band-aid
A bleeding heart is a metaphor.
A leaking one is a common, and often deadly, reality.
In conditions from Duchenne muscular dystrophy to heart attack and heart failure, leaky heart cells lose proteins vital to long-term survival. For University of Minnesota heart researcher Joseph Metzger, fixing these leaks is a prime concern.
He is part of a U team that has built and used molecules akin to plastic as “molecular band-aids” to repair tears in the cell membranes that enclose muscle cells, keeping those vital proteins inside. Collectively, the patches are known as poloxamers.
“The FDA has approved one form of poloxamer for clinical trials with boys who have Duchenne muscular dystrophy,” says Metzger, head of the Department of Integrative Biology and Physiology. “But [we still must secure] funds for the trials.”
Metzger’s colleagues are Frank Bates, head of the Department of Chemical Engineering and Materials Science, and cardiologist Demetri Yannopoulos, an assistant professor of medicine. Continue reading